Jornada REMA

May 20th, 2008

Ministry of Health

Madrid (Spain)



Final Agenda


Bottlenecks in the application of 3Rs in the R&D process in the pharmaceutical industry



Session 1: Inauguration

Chair: Dr. Argelia Castaño (President REMA, Spain)

09:00 - 09:30 Presentation of the workshop – VP ECOPA – Authorities


09:30 - 10:00 Opening lecture: The R& D Process in the Pharmaceutical Industry. Prof. Friedlieb Pfannkuch (Vice President, Non Clinical Safety, Hoffmann-La Roche, Switzerland)


Session 2: Hit to Lead

Chair: Dr. Domingo Gargallo (GSK & REMA, Spain)


10:00 - 10:30 In silico prediction of toxic effects. A project of the Spanish Platform of Innovative Medicines. Dr. Ferrán Sanz, (Universitat Pompeu Fabra & Spanish Mirror Platform on Innovative Medicines, Spain)


10:30 - 11:00 In silico prediction of metabolism. Dr. Per Garber (Bio Vitrium, Sweden)


11:00 - 11:30 Coffee Break


Session 3: Lead to Candidate

Chair: José Vicente Castell (Fundación La Fe & REMA, Spain)


11:30 - 12:00   Anticipating brain-blood barrier permeability of drugs. Romeo Ceccelli (University of Artois)


12:00 - 12:30   Drug Hepatotoxicity. Dr. María-José Gómez Lechón/ Dr. José Vicente Castell (Centro de Investigación, Hospital La Fe & REMA, Spain)


12:30 - 13:00   Use of Zebrafish in toxicology screening. Dr. Philippe Vanparys (Center for Advanced R&D on Alternative Methods - CARDAM - , Belgium; former at Johnson & Johnson)


Session 4: Regulatory Development


Chair: Joan-Albert Vericat (Neuropharma SA & REMA)


13:00 - 13:30   Drug carcinogenesis assessment. Dr. Eckhard Keutz, Senior Vice President, Global Head Toxicology, Bayer HealhCare AG


13:30 - 14:00   The difficulties in accepting new guidelines. Dr. Carmen Díez, Spanish Agency for Medicines and Healthcare Products, Preclinical Evaluation.


Lunch time 14:00 – 15:30


Session 5: Conclusions & Round Table

Chair: Javier Urzay (Farmaindustria, Spain) y Belén Sopesén (Neuropharma SA, Spain)


15:30 – 16:00 Conclusions from sessions 1-4. Dr. Joan-Albert Vericat, Neuropharma SA, IVTIP & REMA, Spain.


16:00 – 17:00 Round Table: Towards the 4thR: Responsibility in Research. Dr. JV Castell, Dr. D Gargallo, Dr. JA Vericat


17:30   End of the Meeting